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- The likelihood of cognitive enhancement.[Pharmacol Biochem Behav. 2011]
- Smart drugs and synthetic androgens for cognitive and physical enhancement: revolving doors of cosmetic neurology.[Curr Neuropharmacol. 2015]
- Addiction-related gene regulation: risks of exposure to cognitive enhancers vs. other psychostimulants.[Prog Neurobiol. 2013]
- Cognitive effects of methylphenidate in healthy volunteers: a review of single dose studies.[Int J Neuropsychopharmacol. 2014]
- The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders.[Psychopharmacology (Berl). 2013]
- Moral and social reasons to acknowledge the use of cognitive enhancers in competitive-selective contexts[BMC Medical Ethics. 2016]
- Pharmacological profiling of zebrafish behavior using chemical and genetic classification of sleep-wake modifiers[Frontiers in Pharmacology. 2015]
- A groundwork for allostatic neuro-education[Frontiers in Psychology. 2015]
- Smart Drugs and Synthetic Androgens for Cognitive and Physical Enhancement: Revolving Doors of Cosmetic Neurology[Current Neuropharmacology. 2015]
- Performance enhancement in the workplace: why and when healthy individuals should disclose their reliance on pharmaceutical cognitive enhancers[Frontiers in Systems Neuroscie...]
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Performance enhancement at the cost of potential brain plasticity: neural ramifi...Performance enhancement at the cost of potential brain plasticity: neural ramifications of nootropic drugs in the healthy developing brainFrontiers in Systems Neuroscience. 2014; 8()
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Methylphenidate produces selective enhancement of declarative memory consolidati...Methylphenidate produces selective enhancement of declarative memory consolidation in healthy volunteersSpringer Open Choice. 2012 Jun; 221(4)611
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Non-specific effects of methylphenidate (Ritalin) on cognitive ability and decis...Non-specific effects of methylphenidate (Ritalin) on cognitive ability and decision-making of ADHD and healthy adults.Psychopharmacology (Berl). 2010 Jul;210(4):511-9. doi: 10.1007/s00213-010-1853-4. Epub 2010 Apr 28.PubMed
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Dextroamphetamine. Its cognitive and behavioral effects in normal and hyperactiv...Dextroamphetamine. Its cognitive and behavioral effects in normal and hyperactive boys and normal men.Arch Gen Psychiatry. 1980 Aug;37(8):933-43.PubMed
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Emergence of tics in children with attention deficit hyperactivity disorder trea...Emergence of tics in children with attention deficit hyperactivity disorder treated with stimulant medications.Compr Psychiatry. 2001 May-Jun;42(3):228-33.PubMed
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Review Methylphenidate: its pharmacology and uses.[Mayo Clin Proc. 2000]Mayo Clin Proc. 2000 Jul; 75(7):711-21.
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Review Overdose of drugs for attention-deficit hyperactivity disorder: clinical presentation, mechanisms of toxicity, and management.[CNS Drugs. 2013]CNS Drugs. 2013 Jul; 27(7):531-43.
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Review Stimulant actions in rodents: implications for attention-deficit/hyperactivity disorder treatment and potential substance abuse.[Biol Psychiatry. 2005]Biol Psychiatry. 2005 Jun 1; 57(11):1391-6.
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Dextroamphetamine: cognitive and behavioral effects in normal prepubertal boys.[Science. 1978]Science. 1978 Feb 3; 199(4328):560-3.
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Dextroamphetamine. Its cognitive and behavioral effects in normal and hyperactive boys and normal men.[Arch Gen Psychiatry. 1980]Arch Gen Psychiatry. 1980 Aug; 37(8):933-43.
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Review Methylphenidate (Ritalin): behavioral studies in the rat.[Int J Neurosci. 2007]Int J Neurosci. 2007 Jun; 117(6):757-94.
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Methylphenidate improves performance on the radial arm maze in periadolescent rats.[Neurotoxicol Teratol. 2008]Neurotoxicol Teratol. 2008 Sep-Oct; 30(5):419-27.
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Non-specific effects of methylphenidate (Ritalin) on cognitive ability and decision-making of ADHD and healthy adults.[Psychopharmacology (Berl). 2010]Psychopharmacology (Berl). 2010 Jul; 210(4):511-9.
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Methylphenidate produces selective enhancement of declarative memory consolidation in healthy volunteers.[Psychopharmacology (Berl). 2012]Psychopharmacology (Berl). 2012 Jun; 221(4):611-9.
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Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function.[Biol Psychiatry. 2006]Biol Psychiatry. 2006 Nov 15; 60(10):1111-20.
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Review Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions.[Biol Psychiatry. 2005]Biol Psychiatry. 2005 Jun 1; 57(11):1377-84.
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Review Toward a new understanding of attention-deficit hyperactivity disorder pathophysiology: an important role for prefrontal cortex dysfunction.[CNS Drugs. 2009]CNS Drugs. 2009; 23 Suppl 1():33-41.
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[Seasonal fluctuations in the catecholamine content in the brain of white rats].[Biull Eksp Biol Med. 1980]Biull Eksp Biol Med. 1980 Feb; 89(2):215-7.
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Chemical sympathectomy and diurnal fluctuations of noradrenaline calorigenic action in the rat.[Arch Int Physiol Biochim. 1980]Arch Int Physiol Biochim. 1980 Aug; 88(3):273-6.
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Cognitive enhancement, cheating, and accomplishment.[Kennedy Inst Ethics J. 2010]Kennedy Inst Ethics J. 2010 Jun; 20(2):145-60.
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Non-medical use of prescription stimulants and illicit use of stimulants for cognitive enhancement in pupils and students in Germany.[Pharmacopsychiatry. 2011]Pharmacopsychiatry. 2011 Mar; 44(2):60-6.
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Review The adolescent brain.[Ann N Y Acad Sci. 2008]Ann N Y Acad Sci. 2008 Mar; 1124():111-26.
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Age-related changes in corticosteroid receptor expression and monoamine neurotransmitter concentrations in various brain regions of postnatal pigs.[J Neurosci Res. 2011]J Neurosci Res. 2011 Jul; 89(7):1134-41.
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Does repetitive Ritalin injection produce long-term effects on SD female adolescent rats?[Neuropharmacology. 2009]Neuropharmacology. 2009 Sep; 57(3):201-7.
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Repetitive ritalin treatment modulates the diurnal activity pattern of young SD male rats.[Cent Nerv Syst Agents Med Chem. 2010]Cent Nerv Syst Agents Med Chem. 2010 Sep 1; 10(3):247-57.
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Methylphenidate preferentially increases catecholamine neurotransmission within the prefrontal cortex at low doses that enhance cognitive function.[Biol Psychiatry. 2006]Biol Psychiatry. 2006 Nov 15; 60(10):1111-20.
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Distinct age-dependent effects of methylphenidate on developing and adult prefrontal neurons.[Biol Psychiatry. 2012]Biol Psychiatry. 2012 Nov 15; 72(10):880-8.
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Review Stress signalling pathways that impair prefrontal cortex structure and function.[Nat Rev Neurosci. 2009]Nat Rev Neurosci. 2009 Jun; 10(6):410-22.
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Maturation of human cerebrum observed in vivo during adolescence.[Brain. 1991]Brain. 1991 Oct; 114 ( Pt 5)():2037-49.
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Review Plasticity of the primate prefrontal cortex.[Neuroscientist. 2007]Neuroscientist. 2007 Jun; 13(3):229-40.
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Review Healthy and abnormal development of the prefrontal cortex.[Dev Neurorehabil. 2009]Dev Neurorehabil. 2009; 12(5):279-97.
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Adolescent rats show cognitive rigidity in a test of attentional set shifting.[Dev Psychobiol. 2011]Dev Psychobiol. 2011 May; 53(4):391-401.
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Review Human prefrontal cortex: evolution, development, and pathology.[Prog Brain Res. 2012]Prog Brain Res. 2012; 195():191-218.
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Review A role for synaptic plasticity in the adolescent development of executive function.[Transl Psychiatry. 2013]Transl Psychiatry. 2013 Mar 5; 3():e238.
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Review NMDA receptor subunits: diversity, development and disease.[Curr Opin Neurobiol. 2001]Curr Opin Neurobiol. 2001 Jun; 11(3):327-35.
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A specialized NMDA receptor function in layer 5 recurrent microcircuitry of the adult rat prefrontal cortex.[Proc Natl Acad Sci U S A. 2008]Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16791-6.
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NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex.[Neuron. 2013]Neuron. 2013 Feb 20; 77(4):736-49.
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A specialized NMDA receptor function in layer 5 recurrent microcircuitry of the adult rat prefrontal cortex.[Proc Natl Acad Sci U S A. 2008]Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16791-6.
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NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex.[Neuron. 2013]Neuron. 2013 Feb 20; 77(4):736-49.
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Treatment with a clinically-relevant dose of methylphenidate alters NMDA receptor composition and synaptic plasticity in the juvenile rat prefrontal cortex.[Neurobiol Learn Mem. 2013]Neurobiol Learn Mem. 2013 Mar; 101():65-74.
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Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.[J Neurosci. 2004]J Neurosci. 2004 Sep 8; 24(36):7821-8.
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Metaplastic regulation of long-term potentiation/long-term depression threshold by activity-dependent changes of NR2A/NR2B ratio.[J Neurosci. 2009]J Neurosci. 2009 Jul 8; 29(27):8764-73.
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Distinct roles of NR2A and NR2B cytoplasmic tails in long-term potentiation.[J Neurosci. 2010]J Neurosci. 2010 Feb 17; 30(7):2676-85.
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Review The neural basis of addiction: a pathology of motivation and choice.[Am J Psychiatry. 2005]Am J Psychiatry. 2005 Aug; 162(8):1403-13.
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Review New medications for drug addiction hiding in glutamatergic neuroplasticity.[Mol Psychiatry. 2011]Mol Psychiatry. 2011 Oct; 16(10):974-86.
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Review Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission.[Neuron. 2005]Neuron. 2005 Mar 3; 45(5):647-50.
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Adolescent rats show cognitive rigidity in a test of attentional set shifting.[Dev Psychobiol. 2011]Dev Psychobiol. 2011 May; 53(4):391-401.
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Differential patterns of regional c-Fos induction in the rat brain by amphetamine and the novel wakefulness-promoting agent modafinil.[Neurosci Lett. 1998]Neurosci Lett. 1998 Jan 30; 241(2-3):95-8.
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Involvement of central histaminergic systems in modafinil-induced but not methylphenidate-induced increases in locomotor activity in rats.[Eur J Pharmacol. 2008]Eur J Pharmacol. 2008 Jan 14; 578(2-3):209-15.
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Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil.[J Pharmacol Exp Ther. 2009]J Pharmacol Exp Ther. 2009 May; 329(2):738-46.
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Modafinil increases histamine release in the anterior hypothalamus of rats.[Neurosci Lett. 2003]Neurosci Lett. 2003 Mar 20; 339(2):143-6.
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Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates.[Neuroscience. 2005]Neuroscience. 2005; 130(4):983-95.
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Modafinil for excessive sleepiness associated with chronic shift work sleep disorder: effects on patient functioning and health-related quality of life.[Prim Care Companion J Clin Psychiatry. 2007]Prim Care Companion J Clin Psychiatry. 2007; 9(3):188-94.
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Modafinil attenuates disruptions in cognitive performance during simulated night-shift work.[Neuropsychopharmacology. 2006]Neuropsychopharmacology. 2006 Jul; 31(7):1526-36.
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Modafinil in the treatment of excessive daytime sleepiness in children.[Sleep Med. 2003]Sleep Med. 2003 Nov; 4(6):579-82.
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Review Current treatment of selected pediatric sleep disorders.[Neurotherapeutics. 2012]Neurotherapeutics. 2012 Oct; 9(4):791-800.
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Toxicity from modafinil ingestion.[Clin Toxicol (Phila). 2009]Clin Toxicol (Phila). 2009 Feb; 47(2):153-6.
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Cognitive enhancing effects of modafinil in healthy volunteers.[Psychopharmacology (Berl). 2003]Psychopharmacology (Berl). 2003 Jan; 165(3):260-9.
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Effects of modafinil on cognitive and meta-cognitive performance.[Hum Psychopharmacol. 2004]Hum Psychopharmacol. 2004 Jul; 19(5):323-32.
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Does modafinil enhance cognitive performance in young volunteers who are not sleep-deprived?[J Clin Psychopharmacol. 2005]J Clin Psychopharmacol. 2005 Apr; 25(2):175-9.
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Effects of modafinil on working memory processes in humans.[Psychopharmacology (Berl). 2004]Psychopharmacology (Berl). 2004 Dec; 177(1-2):161-9.
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Cognitive effects of modafinil in student volunteers may depend on IQ.[Pharmacol Biochem Behav. 2005]Pharmacol Biochem Behav. 2005 Sep; 82(1):133-9.
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Differential effects of modafinil and methylphenidate on stop-signal reaction time task performance in the rat, and interactions with the dopamine receptor antagonist cis-flupenthixol.[Psychopharmacology (Berl). 2007]Psychopharmacology (Berl). 2007 Jun; 192(2):193-206.
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Effects of modafinil and methylphenidate on visual attention capacity: a TVA-based study.[Psychopharmacology (Berl). 2010]Psychopharmacology (Berl). 2010 Jun; 210(3):317-29.
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Modulatory effects of modafinil on neural circuits regulating emotion and cognition.[Neuropsychopharmacology. 2010]Neuropsychopharmacology. 2010 Sep; 35(10):2101-9.
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Review The adolescent brain.[Ann N Y Acad Sci. 2008]Ann N Y Acad Sci. 2008 Mar; 1124():111-26.
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Distinct age-dependent effects of methylphenidate on developing and adult prefrontal neurons.[Biol Psychiatry. 2012]Biol Psychiatry. 2012 Nov 15; 72(10):880-8.
-
Treatment with a clinically-relevant dose of methylphenidate alters NMDA receptor composition and synaptic plasticity in the juvenile rat prefrontal cortex.[Neurobiol Learn Mem. 2013]Neurobiol Learn Mem. 2013 Mar; 101():65-74.
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Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons.[J Clin Invest. 2007]J Clin Invest. 2007 Dec; 117(12):4022-33.
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Review The likelihood of cognitive enhancement.[Pharmacol Biochem Behav. 2011]Pharmacol Biochem Behav. 2011 Aug; 99(2):116-29.
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Review Cognitive enhancers: focus on modulatory signaling influencing memory consolidation.[Pharmacol Biochem Behav. 2011]Pharmacol Biochem Behav. 2011 Aug; 99(2):155-63.
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Mechanism based approaches for rescuing and enhancing cognition.[Front Neurosci. 2013]Front Neurosci. 2013 Aug 15; 7():143.
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Cognitive enhancing effects of modafinil in healthy volunteers.[Psychopharmacology (Berl). 2003]Psychopharmacology (Berl). 2003 Jan; 165(3):260-9.
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Does modafinil enhance cognitive performance in young volunteers who are not sleep-deprived?[J Clin Psychopharmacol. 2005]J Clin Psychopharmacol. 2005 Apr; 25(2):175-9.
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Improvement of learning processes following chronic systemic administration of modafinil in mice.[Pharmacol Biochem Behav. 2002]Pharmacol Biochem Behav. 2002 Oct; 73(3):723-8.
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Effects of modafinil on working memory processes in humans.[Psychopharmacology (Berl). 2004]Psychopharmacology (Berl). 2004 Dec; 177(1-2):161-9.
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Review Modafinil: a review of neurochemical actions and effects on cognition.[Neuropsychopharmacology. 2008]Neuropsychopharmacology. 2008 Jun; 33(7):1477-502.
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Methylphenidate improves working memory and set-shifting in AD/HD: relationships to baseline memory capacity.[J Child Psychol Psychiatry. 2004]J Child Psychol Psychiatry. 2004 Feb; 45(2):293-305.
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Review Cognitive effects of immediate-release methylphenidate in children with attention-deficit/hyperactivity disorder.[Neurosci Biobehav Rev. 2006]Neurosci Biobehav Rev. 2006; 30(8):1225-45.
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Effects of methylphenidate on working memory functioning in children with attention deficit/hyperactivity disorder.[Eur J Paediatr Neurol. 2009]Eur J Paediatr Neurol. 2009 Nov; 13(6):516-23.
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Pattern classification of working memory networks reveals differential effects of methylphenidate, atomoxetine, and placebo in healthy volunteers.[Neuropsychopharmacology. 2011]Neuropsychopharmacology. 2011 May; 36(6):1237-47.
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Review Pharmacology of ampakine modulators: from AMPA receptors to synapses and behavior.[Curr Drug Targets. 2007]Curr Drug Targets. 2007 May; 8(5):583-602.
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Review AMPA receptor trafficking and synaptic plasticity.[Annu Rev Neurosci. 2002]Annu Rev Neurosci. 2002; 25():103-26.
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AMPARs and synaptic plasticity: the last 25 years.[Neuron. 2013]Neuron. 2013 Oct 30; 80(3):704-17.
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Review The glutamate receptor ion channels.[Pharmacol Rev. 1999]Pharmacol Rev. 1999 Mar; 51(1):7-61.
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Review NMDA receptor subunits: diversity, development and disease.[Curr Opin Neurobiol. 2001]Curr Opin Neurobiol. 2001 Jun; 11(3):327-35.
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Review NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease.[Nat Rev Neurosci. 2013]Nat Rev Neurosci. 2013 Jun; 14(6):383-400.
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Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons.[Neuron. 2001]Neuron. 2001 Jan; 29(1):243-54.
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A placebo-controlled pilot study of the ampakine CX516 added to clozapine in schizophrenia.[J Clin Psychopharmacol. 2001]J Clin Psychopharmacol. 2001 Oct; 21(5):484-7.
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Brain-derived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndrome.[J Neurosci. 2007]J Neurosci. 2007 Oct 3; 27(40):10912-7.
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Acute effects of the ampakine farampator on memory and information processing in healthy elderly volunteers.[Neuropsychopharmacology. 2007]Neuropsychopharmacology. 2007 Jun; 32(6):1272-83.
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Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice.[Proc Natl Acad Sci U S A. 2009]Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4906-11.
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Ampakines promote spine actin polymerization, long-term potentiation, and learning in a mouse model of Angelman syndrome.[Neurobiol Dis. 2012]Neurobiol Dis. 2012 Aug; 47(2):210-5.
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AMPAKINE enhancement of social interaction in the BTBR mouse model of autism.[Neuropharmacology. 2013]Neuropharmacology. 2013 Jan; 64():268-82.
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Delayed increase of Ca2+ influx elicited by glutamate: role in neuronal death.[Mol Pharmacol. 1989]Mol Pharmacol. 1989 Jul; 36(1):106-12.
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Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function.[Neuron. 1995]Neuron. 1995 Oct; 15(4):961-73.
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Ampakines promote spine actin polymerization, long-term potentiation, and learning in a mouse model of Angelman syndrome.[Neurobiol Dis. 2012]Neurobiol Dis. 2012 Aug; 47(2):210-5.
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Review Systematic review of pharmacological treatments in fragile X syndrome.[BMC Neurol. 2009]BMC Neurol. 2009 Oct 13; 9():53.
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AMPAKINE enhancement of social interaction in the BTBR mouse model of autism.[Neuropharmacology. 2013]Neuropharmacology. 2013 Jan; 64():268-82.
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Review Axon retraction and degeneration in development and disease.[Annu Rev Neurosci. 2005]Annu Rev Neurosci. 2005; 28():127-56.
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Review Experience and the developing prefrontal cortex.[Proc Natl Acad Sci U S A. 2012]Proc Natl Acad Sci U S A. 2012 Oct 16; 109 Suppl 2():17186-93.
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Review Autism and abnormal development of brain connectivity.[J Neurosci. 2004]J Neurosci. 2004 Oct 20; 24(42):9228-31.
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Ampakines and the threefold path to cognitive enhancement.[Trends Neurosci. 2006]Trends Neurosci. 2006 Oct; 29(10):554-62.
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Review Hippocampal long-term depression: master or minion in declarative memory processes?[Trends Neurosci. 2007]Trends Neurosci. 2007 Mar; 30(3):111-8.
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Review Evolution of the Study of Methylphenidate and Its Actions on the Adult Versus Juvenile Brain.[J Atten Disord. 2015]J Atten Disord. 2015 Jul; 19(7):603-19.
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Review Methylphenidate and the juvenile brain: enhancement of attention at the expense of cortical plasticity?[Med Hypotheses. 2013]Med Hypotheses. 2013 Dec; 81(6):988-94.
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Distinct age-dependent effects of methylphenidate on developing and adult prefrontal neurons.[Biol Psychiatry. 2012]Biol Psychiatry. 2012 Nov 15; 72(10):880-8.